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瘦的人也会得肝脂肪变性吗?

2020-09-30 00:03:58梅斯医学
核心提示:我们知道,肥胖和非酒精性脂肪肝疾病(NAFLD)的发病率在不断增加,虽然通常在肥胖患者中肝脂肪变性更容易发生,但对于没有典型危险因素的瘦肉患者,肝脂肪病变是否也会发生呢,这有待进一步的探究。因此,在本项研究中研究人员旨在确定在体瘦患者中肝脂肪变性的发生率和危险因素。

  WOMENZHIDAO,FEIPANGHEFEIJIUJINGXINGZHIFANGGANJIBING(NAFLD)DEFABINGLVZAIBUDUANZENGJIA,SUIRANTONGCHANGZAIFEIPANGHUANZHEZHONGGANZHIFANGBIANXINGGENGRONGYIFASHENG,DANDUIYUMEIYOUDIANXINGWEIXIANYINSUDESHOUROUHUANZHE,GANZHIFANGBINGBIANSHIFOUYEHUIFASHENGNI,ZHEIYOUDAIJINYIBUDETANJIU。YINCI,ZAIBENXIANGYANJIUZHONGYANJIURENYUANZHIZAIQUEDINGZAITISHOUHUANZHEZHONGGANZHIFANGBIANXINGDEFASHENGLVHEWEIXIANYINSU。

  YANJIURENYUANHUIGUXINGSHOUJIWEIFASHENGBINGDUXINGGANYANQIEBMI≤25 kg/m2DETISHOUHUANZHE,TONGGUOSHUNSHIDANXINGCHENGXIANGJINXINGGANYINGDUCELIANG(LSM)HESHOUKONGSHUAIJIANCANSHU(CAP)DECELIANG。

  ZUIHOUYOU218MINGHUANZHEBEINARUBENXIANGYANJIU,QIZHONG34.5%DEHUANZHEXIANSHICHUGANZHIFANGBIANXING(CAP≥268FENBEI/MI),GANZHIFANGBIANXINGHUANZHEDE GUXIANZHUANTAIMEI(GGT) JIAOGAO(238.0 vs.112.1IU/mL; p= 0.013),AST(63(±67.4)vs.38.5(±32.9)IU / mL; p ?= 0.001)HEALT(59.1(±58.8)vs. 44.3(±52.7)IU / mL; p ?= 0.048)YEJUNJIAOGAO,BINGXIANSHIQUYUGENGYANZHONGDEXIANWEIHUADEQUSHI(LSM 15.6(±19.5)vs. 12.0(±15.7)kPa; p?= 0.115),ZAIDUOYUANHUIGUIFENXIZHONG,ZHIYOUXUEQINGNIAOSUANSHUIPINGYUGANZHIFANGBIANXINGDULIXIANGGUAN(ORWEI1.43 /MEIDANWEImg / dL; 95%CI 1.001–2.054;p = 0.049)。ZAI38.9GEYUEDEPINGJUNSUIFANGQIJIAN,14LIHUANZHE(5.0%)SIWANG。ZAIMEIYOUWANQIXIANWEIHUADEQINGKUANGXIA,WUZHIFANGBIANXING(98.7%)HEZHIFANGBIANXING(98.6%)DEHUANZHEZAI1NIANHOUDECUNHUOLVXIANGSI。

  ZUIHOUYANJIURENYUANSHUODAO:XUEQINGNIAOSUANSHUIPINGGAOHUIZENGJIASHOUHUANZHEGANZHIFANGBIANXINGDEFENGXIAN。GANXIANWEIHUAERFEIGANZHIFANGBIANXINGSHISHOURUOHUANZHESHENGCUNSHOUSUNDEWEIXIANYINSU。

  YUANSHICHUCHU:

  Lukas W. Unger. Et al. Hepatic Steatosis in Lean Patients: Risk Factors and Impact on Mortality. Digestive Diseases and Sciences.2020.

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