QIANGLVKUIZAIMEIGUOBEIGAODUZHENGZHIHUA，ZHEIYECUSHITACHENGWEIQIJINWEIZHIZUIJUZHENGYIXINGDEYAOWU。ZUOWEIXINGUANDALIUXINGZHONGYANJIUZUIDUODEYAOWUZHIYI，YOUGUANQIANGLVKUIDEYANJIUJIELUNSIHUZONGSHIXIANGHUMAODUNDE。SUOXING8YUEFABIAODEJIXIANGHUICUIFENXIXIAOCHULEYIXIEQIYI。

　　WANGSHIHUIGU，SANDAHUICUIFENXICHENGQIANGLVKUIZHILIAOXINGUAN“ZHONGJIEZHE”？

　　1.羟氯喹治疗新冠死亡率荟萃分析

　　8YUE26RI，YIPIANTIWEI "Effect of hydroxychloroquine with or without azithromycin on the mortality of coronavirus disease 2019 (COVID-19) patients： a systematic review and meta-analysis"DEWENZHANGFABIAOZAI《LINCHUANGWEISHENGWUXUEYUGANRAN》（CMI）SHANG，TONGGUOXITONGHUIGUHEHUICUIFENXICHANSHULEQIANGLVKUIJIAHUOBUJIAAQIMEISUDUIXINGUANHUANZHESIWANGLVDEYINGXIANG。

　　YANJIUNARU29PIANFUHEBIAOZHUNDEYANJIU，QIZHONG1PIANWEIFEIZHUYUANHUANZHEYANJIU，3PIANWEISUIJIDUIZHAOSHIYAN，25PIANWEIGUANCHAXINGYANJIU。ZAIPAICHUJUYOULINJIEPIANYIFENGXIANDEYANJIUHOU，HUICUIFENXINARULE11932MINGQIANGLVKUIZUCANYUZHE，8081MINGQIANGLVKUI+AQIMEISUZUCANYUZHE，YIJI12930MINGDUIZHAOZUCANYUZHE。JIEGUOXIANSHI：

　　QIANGLVKUIYUSIWANGLVWUXIANZHUXIANGGUANXING：SUOYOUYANJIUDEHUIZONGXIANGDUIFENGXIAN（RR）WEI0.83（95% CI 0.65-1.06，n = 17XIANGYANJIU），SUIJIDUIZHAOSHIYANDERR = 1.09（95% CI 0.97-1.24，n = 3XIANGYANJIU）。YUDUIZHAOZUXIANGBISIWANGFENGXIANJIANGDILE17%（JUEDUIFENGXIAN：-4.4%），DANZHEIYIJIEGUOMEIYOUDADAOTONGJIXUEYIYI。

　　QIANGLVKUI+AQIMEISUYUSIWANGLVZENGJIAXIANGGUAN（RR = 1.27；95% CI 1.04-1.54，n = 7XIANGYANJIU）。YUDUIZHAOZUXIANGBI，SIWANGFENGXIANZENGJIALE27%（JUEDUIFENGXIAN：+7%），CHAYIJUYOUTONGJIXUEYIYI。DANWEIYIYIXIANGSUIJIDUIZHAOYANJIUMEIYOUFAXIANXIANZHUCHAYI。

　　ZHEIXIANGHUICUIFENXIBIAOMING，DANYONGQIANGLVKUIDUIXINGUANHUANZHEZHILIAOWUXIAO，LIANHEAQIMEISUSHIYONGHUIZENGJIAHUANZHESIWANGFENGXIAN。GAIJIEGUOYEYU7YUEFABIAODEYIXIANGZONGHE13XIANGXINGUANYANJIUDEHUICUIFENXIYIZHI，DANNARUDEYANJIUZHENGJUZHILIANGJIAODI。

　　2.羟氯喹治疗新冠临床进展情况荟萃分析

　　GAIYANJIUYU8YUE18RIFABIAOZAI《YIXUEBINGDUXUEZAZHI》（JMV）SHANG，WEIZHENDUIQIANGLVKUIZHILIAOFEIZHONGDUXINGUANHUANZHEDUIZHAOLINCHUANGSHIYANDEXITONGHUIGUHEHUICUIFENXI。TONGGUODUI6XIANGANWEIJIDUIZHAOYANJIUDEKAOCHA，YANJIUZHEFAXIAN：

　　QIANGLVKUIXIANGDUIYUDUIZHAOZUNENGXIANZHUYUFANGZAOQIFANGSHEXUEJINZHAN，FENGXIANCHAYIHE95%ZHIXINQUJIANWEI-0.2（-0.36～-0.03）（2XIANGYANJIU）。

　　QIANGLVKUIBUNENGFANGZHIXINGUANLINCHUANGJINZHAN（4XIANGYANJIU），BUNENGJIANGDI5TIANSIWANGLV（2XIANGYANJIU）。

　　QIANGLVKUIYEBUNENGTIGAO5、6、7TIANDEBINGDUQINGCHULV（3XIANGYANJIU）。

　　CIWAI，QIANGLVKUIZHILIAOYOUXUDUOBULIANGFANYINGDEBAODAO。BAOKUOWEICHANGDAO、SHENJINGXITONG、PIFU、XINZANGFUZUOYONG。

　　YOUCIKANLAI，QIANGLVKUIWEINENGXIANSHICHUXINGUANBINGDUQINGCHUHUOLINCHUANGHUOYI，SUIRANKEYIJIANHUANFEIBUSUNSHANG，DANYOUYUMEIYOUGAISHANZHONGYAOLINCHUANGZHIBIAO，RUZHENGZHUANGJINZHAN、SIWANGLVDENG，SUOYISIHULINCHUANGJIAZHIWEIBUZUDAO，LINGWAIFANERDAILAILEEWAIDEFUZUOYONG。

　　3.羟氯喹安全性荟萃分析

　　8YUE11RI，《OUZHOULINCHUANGYAOLIXUEZAZHI》（Eur J Clin Pharmacol）FABIAOLETIWEI "Safety of hydroxychloroquine in COVID-19 and other diseases： a systematic review and meta-analysis of 53 randomized trials"DEWENZHANG，TANTAOLEQIANGLVKUIZAIXINGUANZHILIAOHEQITAJIBINGZHONGDEANQUANXING。

　　YANJIUQUEDINGLE53XIANGFUHETIAOJIANDEYANJIU，SHEJI5496MINGHUANZHE。FENXIXIANSHI，YUDUIZHAOZUXIANGBI，QIANGLVKUIZUDEBULIANGFANYING（AEs）FENGXIANXIANZHUZENGJIA（RD 0.05，95%CI，0.02～0.07，P = 0. 0002），ZAIXINGUANYAZU（RD 0.15，95%CI，0.07～0.23，P = 0.0002）YIJIQITAJIBINGYAZU（RD 0.03，95%CI，0.01～0.04，P = 0.003），CHAYIYEYOUTONGJIXUEYIYI。HUIZONGJIEGUORUXIA：

　　YIBANFUZUOYONG（44XIANGYANJIU，4XIANGGUANYUXINGUAN）：XINGUANJUEDUIFENGXIANZENGJIA15%，QITAJIBINGHUANZHEZENGJIA3%。ZAIYAZUFENXIZHONG，GAOQIANGLVKUIJILIANGDAOZHIXINGUANHUANZHEJUEDUIFENGXIANZENGJIA19%。

　　WEICHANGDAOFUZUOYONG（32XIANGYANJIU，2XIANGGUANYUXINGUAN）：XINGUANHUANZHEJUEDUIFENGXIANZENGJIA11%，QITAJIBINGHUANZHEZENGJIA3%。

　　PIFUFUZUOYONG（28XIANGYANJIU；3XIANGGUANYUXINGUAN）：XINGUANHUANZHEWUBIANHUA，DANQITAJIBINGHUANZHEJUEDUIFENGXIANZENGJIA2%。

　　YANBUFUZUOYONG（30XIANGYANJIU，2XIANGGUANYUXINGUAN）：SUOYOUHUANZHEWUBIANHUA。

　　XINZANGFUZUOYONG（9XIANGYANJIU，1XIANGGUANYUXINGUAN）：SUOYOUHUANZHEWUBIANHUA。

　　YANZHONGFUZUOYONG（36XIANGYANJIU，4XIANGGUANYUXINGUAN）：SUOYOUHUANZHEWUBIANHUA。

　　ZHEIXIANGHUICUIFENXIYANZHENGLEQIANGLVKUIHUIJIBAOKUOXINGUANHUANZHEZAINEIDEHUANZHEDAILAIEWAIFUZUOYONG，YOUQISHIWEICHANGXITONGFUZUOYONG。YUZONGTIRENQUNZHONGDEANWEIJIHUOWUGANYUCUOSHIXIANGBI，QIANGLVKUIYUGAOAEsZONGFENGXIANXIANGGUAN。DANJIANYUNARUDEXINGUANCANYUZHESHULIANGJIAOSHAO，YINGGAIJINSHENDUIDAIZHEIYIJIELUN。

　　JIYUZHEIXIEHUICUIFENXIJIEGUO，QIANGLVKUIZHILIAOXINGUANWUXIAOQIEYOUHAIDEZHENGJUSIHUJINYIBUZENGJIA，NEIMEKEXUEJIEWANQUANFANGQIQIANGLVKUIYEZAIQINGLIZHIZHONG。6YUEYINGGUONIUJINDAXUERECOVERYSHIYANDEJIEGUO，YEZHISHIXUDUOJIGOUTINGZHILEHCQDESHIYONG。ERQIEMEIGUOFDAYEZAITONGYISHIJIANCHEXIAOLEQIANGLVKUIZAIXINGUANHUANZHEZHONGJINJISHIYONGDESHOUQUAN。

　　RANERSHISHISHANG，JIEZHI9YUE23RI，ZAIMEIGUOGUOLIWEISHENGYANJIUYUAN（NIH）DEClinicalTrials.govZHONG，RENGYOU195XIANGSHEJIQIANGLVKUIDEXINGUANSHIYANZAILIE。

　　NANDAOQIANGLVKUIZAIDALIUXINGZHONGDEYINGYONGHAIYOUXIWANG？ZHEISIHUYUQIYUFANGZUOYONGYOUGUAN。

　　名刊“坐阵”，羟氯喹能否从预防新冠中另辟蹊径？

　　WEISHENMEQIANGLVKUIHAINENGDEDAORUCIGUANGFANDEYANJIU？《XINYINGGELANYIXUEZAZHI》（NEJM）DEYIPIANSHELUNRENWEI，RUGUOQIANGLVKUIZAIXINGUANBAOLUQIANGENGZAODIFUYONG，KENENGHUIQIYUFANGZUOYONG，BINGRENWEIQIQIANZAIYUFANGXIAOYIHAIYOUDAIQUEDING。ZHENGZAIJINXINGDEYIXIELINCHUANGSHIYANJIUSHIYICIWEILIYOU。

　　FENXIYUANYIN，ZHEIKENENGYUACE2SHOUTIZAIXINGUANBINGDUQINRUXIBAOZHIQIANXUYAOJINXINGTANGJIHUA，ERQIANGLVKUIKEYIZUZHITANGJIHUABUZHOUYOUGUAN。

　　LINGWAI，ZAOJIEDUANYANJIUFAXIAN，ZAOQIJIESHOUQIANGLVKUILIANHEXINKEJINYIBUGAISHANXINGUANHUANZHELINCHUANGJIEGUO。KEXUEJIARENWEIQIANGLVKUIKEYICUJINXIBAODUIXINDEXISHOU。ERXINSHIXIBAOCHANSHENGKANGBINGDUFANYINGSUOBIXUDEYINGYANGWUZHI。XINBENSHENKEYIJINYIBUZUZHIBINGDUFUZHISUOXUDEMEI（JIRNAJUHEMEI）。

　　RANER，TONGSHIQIFABIAOZAINEJMSHANGDEYIXIANGRCTYANJIUQUEDAILAIBUHAODEXIAOXI。ZHEIXIANGDUI821MINGWUZHENGZHUANGCANYUZHEBAOLUXINGUANDEYANJIUXIANSHI，ZAIBAOLUHOU4TIANNEIJIYUQIANGLVKUIZAIYUFANGXINGUANFAZHANFANGMIANBINGBUBIANWEIJIHAO。ZHEITISHIDANDUSHIYONGQIANGLVKUIHUOBUNENGZUOWEIYUFANGYAOWUFAHUIZUOYONG。

　　SUOYIWULUNRUHE，RENMENBIXUZAIQIANGLVKUIDEYUFANGYINGYONGYUTAQIANZAIDEFUZUOYONGJIANJINXINGQUANHENG。QIANGLVKUISHIMIANYIDIAOJIEYAOWU，YOUKENENGYIZHIZHENGCHANGDEMIANYIXITONGJIHUO，MUQIANDEYANJIUYEBIAOMING，JIANKANGRENQUNYINGGAIBIMIANSHIYONGTAZUOWEIYUFANGYAOWU，ZHIDAOFAXIANJINYIBUDEYANJIUZHENGJU。

　　ZONGZHI，QIANGLVKUIZUOWEIYIGEZHENGYIYAOWU，ZUIJINDESANXIANGHUICUIFENXIDOURENWEI，QIBUSHIYONGYUXINGUANZHILIAO。ERZAIYUFANGYONGYAOFANGMIAN，SHANGXULINCHUANGSHIYANJINYIBUZHENGMING。DANKEYIKENDINGDESHI，“QIANGLVKUIZHIZHENG”DAILAIDESIKAOZAOYICHAOGUOQIYAOWUYINGYONGBENSHEN。