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羟氯喹仍在为“起死回生”寻求证据

2020-09-27 07:28:51梅斯医学
核心提示:羟氯喹在美国被高度政治化,这也促使它成为迄今为止最具争议性的药物。作为新冠大流行中研究最多的药物之一,有关羟氯喹的研究结论似乎总是相互矛盾的。所幸8月发表的几项荟萃分析消除了一些歧义。

  QIANGLVKUIZAIMEIGUOBEIGAODUZHENGZHIHUA,ZHEIYECUSHITACHENGWEIQIJINWEIZHIZUIJUZHENGYIXINGDEYAOWU。ZUOWEIXINGUANDALIUXINGZHONGYANJIUZUIDUODEYAOWUZHIYI,YOUGUANQIANGLVKUIDEYANJIUJIELUNSIHUZONGSHIXIANGHUMAODUNDE。SUOXING8YUEFABIAODEJIXIANGHUICUIFENXIXIAOCHULEYIXIEQIYI。

  WANGSHIHUIGU,SANDAHUICUIFENXICHENGQIANGLVKUIZHILIAOXINGUAN“ZHONGJIEZHE”?

  1.羟氯喹治疗新冠死亡率荟萃分析

  8YUE26RI,YIPIANTIWEI "Effect of hydroxychloroquine with or without azithromycin on the mortality of coronavirus disease 2019 (COVID-19) patients: a systematic review and meta-analysis"DEWENZHANGFABIAOZAI《LINCHUANGWEISHENGWUXUEYUGANRAN》(CMI)SHANG,TONGGUOXITONGHUIGUHEHUICUIFENXICHANSHULEQIANGLVKUIJIAHUOBUJIAAQIMEISUDUIXINGUANHUANZHESIWANGLVDEYINGXIANG。

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  QIANGLVKUIYUSIWANGLVWUXIANZHUXIANGGUANXING:SUOYOUYANJIUDEHUIZONGXIANGDUIFENGXIAN(RR)WEI0.83(95% CI 0.65-1.06,n = 17XIANGYANJIU),SUIJIDUIZHAOSHIYANDERR = 1.09(95% CI 0.97-1.24,n = 3XIANGYANJIU)。YUDUIZHAOZUXIANGBISIWANGFENGXIANJIANGDILE17%(JUEDUIFENGXIAN:-4.4%),DANZHEIYIJIEGUOMEIYOUDADAOTONGJIXUEYIYI。

  QIANGLVKUI+AQIMEISUYUSIWANGLVZENGJIAXIANGGUAN(RR = 1.27;95% CI 1.04-1.54,n = 7XIANGYANJIU)。YUDUIZHAOZUXIANGBI,SIWANGFENGXIANZENGJIALE27%(JUEDUIFENGXIAN:+7%),CHAYIJUYOUTONGJIXUEYIYI。DANWEIYIYIXIANGSUIJIDUIZHAOYANJIUMEIYOUFAXIANXIANZHUCHAYI。

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  2.羟氯喹治疗新冠临床进展情况荟萃分析

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  QIANGLVKUIYEBUNENGTIGAO5、6、7TIANDEBINGDUQINGCHULV(3XIANGYANJIU)。

  CIWAI,QIANGLVKUIZHILIAOYOUXUDUOBULIANGFANYINGDEBAODAO。BAOKUOWEICHANGDAO、SHENJINGXITONG、PIFU、XINZANGFUZUOYONG。

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  3.羟氯喹安全性荟萃分析

  8YUE11RI,《OUZHOULINCHUANGYAOLIXUEZAZHI》(Eur J Clin Pharmacol)FABIAOLETIWEI "Safety of hydroxychloroquine in COVID-19 and other diseases: a systematic review and meta-analysis of 53 randomized trials"DEWENZHANG,TANTAOLEQIANGLVKUIZAIXINGUANZHILIAOHEQITAJIBINGZHONGDEANQUANXING。

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  NANDAOQIANGLVKUIZAIDALIUXINGZHONGDEYINGYONGHAIYOUXIWANG?ZHEISIHUYUQIYUFANGZUOYONGYOUGUAN。

  名刊“坐阵”,羟氯喹能否从预防新冠中另辟蹊径?

  WEISHENMEQIANGLVKUIHAINENGDEDAORUCIGUANGFANDEYANJIU?《XINYINGGELANYIXUEZAZHI》(NEJM)DEYIPIANSHELUNRENWEI,RUGUOQIANGLVKUIZAIXINGUANBAOLUQIANGENGZAODIFUYONG,KENENGHUIQIYUFANGZUOYONG,BINGRENWEIQIQIANZAIYUFANGXIAOYIHAIYOUDAIQUEDING。ZHENGZAIJINXINGDEYIXIELINCHUANGSHIYANJIUSHIYICIWEILIYOU。

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